In Silico Drug Discovery and Virtual Screening
In silico drug discovery uses computational methods including molecular docking, pharmacophore modeling, and virtual screening to identify and optimize potential drug candidates.
BiologyElectrophysiology and Patch Clamp Techniques
Patch clamp electrophysiology measures ion currents through individual channels and whole cells, providing direct observation of channel gating, conductance, and pharmacology.
BiologySurface Forces and Surface Force Apparatus
The surface force apparatus measures intermolecular and surface forces as a function of separation distance, providing direct insight into van der Waals, electrostatic, steric, and solvation forces.
BiologyNatural Products in Drug Discovery
Natural products from plants, microbes, and marine organisms provide a rich source of chemical diversity for drug discovery, with applications in infectious disease, oncology, and immunology.
BiologyAnalytical Ultracentrifugation
Analytical ultracentrifugation determines the molecular weight, shape, and interaction stoichiometry of macromolecules in solution by monitoring sedimentation at high centrifugal forces.
Biology
Personnel Training and Competency Assessment
Personnel training and competency assessment ensure laboratory staff possess the knowledge, skills, and abilities to perform their assigned tasks accurately and reliably.
General
Confocal Laser Scanning Microscopy
Confocal microscopy uses a pinhole aperture to eliminate out-of-focus light, enabling optical sectioning of thick specimens with high resolution and three-dimensional reconstruction.
ChemistryLaboratory Waste Management
Laboratory waste management categorizes, segregates, stores, and disposes of chemical, biological, and radioactive waste in compliance with environmental regulations.
GeneralADME/Tox Profiling in Drug Discovery
ADME/Tox profiling evaluates the absorption, distribution, metabolism, excretion, and toxicity of drug candidates to select compounds with favorable pharmacokinetic and safety profiles.
BiologyDynamic Mechanical Analysis
Dynamic mechanical analysis measures the viscoelastic properties of materials by applying oscillatory stress and recording the resulting strain as a function of temperature, frequency, or time.
ChemistryParticle Size Analysis
Particle size analysis measures the size distribution of particulate materials using techniques including laser diffraction, dynamic light scattering, sieving, and sedimentation.
Chemistry
Phytochemical Analysis and Extraction
Phytochemical analysis encompasses the extraction, separation, identification, and quantification of bioactive plant secondary metabolites including alkaloids, flavonoids, terpenoids, and phenolics.
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