In Silico Drug Discovery and Virtual Screening
In silico drug discovery uses computational methods including molecular docking, pharmacophore modeling, and virtual screening to identify and optimize potential drug candidates.
Chemical biologyElectrophysiology and Patch Clamp Techniques
Patch clamp electrophysiology measures ion currents through individual channels and whole cells, providing direct observation of channel gating, conductance, and pharmacology.
BiophysicsSurface Forces and Surface Force Apparatus
The surface force apparatus measures intermolecular and surface forces as a function of separation distance, providing direct insight into van der Waals, electrostatic, steric, and solvation forces.
BiophysicsNatural Products in Drug Discovery
Natural products from plants, microbes, and marine organisms provide a rich source of chemical diversity for drug discovery, with applications in infectious disease, oncology, and immunology.
Chemical biologyAnalytical Ultracentrifugation
Analytical ultracentrifugation determines the molecular weight, shape, and interaction stoichiometry of macromolecules in solution by monitoring sedimentation at high centrifugal forces.
BiophysicsADME/Tox Profiling in Drug Discovery
ADME/Tox profiling evaluates the absorption, distribution, metabolism, excretion, and toxicity of drug candidates to select compounds with favorable pharmacokinetic and safety profiles.
Chemical biologyPK/PD Modeling in Drug Development
Pharmacokinetic/pharmacodynamic modeling integrates drug concentration-time data with observed effects to predict dosing regimens and optimize therapeutic outcomes.
Chemical biologyMolecular Dynamics Simulations
Molecular dynamics simulations compute the time-dependent motion of atoms and molecules using classical mechanics, revealing conformational changes, binding events, and thermodynamic properties.
BiophysicsBiopharmaceuticals: Monoclonal Antibodies and ADCs
Biopharmaceuticals are therapeutic products derived from biological sources, including monoclonal antibodies, antibody-drug conjugates, and fusion proteins that target specific disease pathways.
Chemical biologyShowing 1 to 12 of 157 results