Hemoglobinopathies: Sickle Cell Disease and Thalassemia
Hemoglobinopathies are genetic disorders of hemoglobin structure or synthesis, including sickle cell disease and the thalassemias.
Anemias Hemolytic Anemias
Hemolytic anemias result from premature destruction of RBCs, classified by site of hemolysis and underlying etiology.
Anemias Iron Deficiency Anemia
Iron deficiency anemia is the most common nutritional deficiency worldwide, characterized by microcytic hypochromic RBCs and depleted iron stores.
Anemias Megaloblastic Anemias
Megaloblastic anemias result from vitamin B12 or folate deficiency, causing impaired DNA synthesis and macrocytic anemia with distinctive morphologic features.
Anemias Introduction to Hematologic Malignancies
Hematologic malignancies are clonal disorders of hematopoietic cells classified by lineage (myeloid/lymphoid) and clinical progression (acute/chronic).
Acute and Chronic Leukemias
Leukemias are clonal hematopoietic neoplasms classified by lineage (myeloid/lymphoid) and clinical pace (acute/chronic) with distinct laboratory features.
Lymphomas
Lymphomas are lymphoid neoplasms arising in lymph nodes or extranodal sites, classified into Hodgkin and non-Hodgkin types with distinct histopathology and immunophenotype.
Plasma Cell Disorders
Plasma cell disorders are clonal proliferations of immunoglobulin-secreting plasma cells, ranging from benign monoclonal gammopathy to multiple myeloma.
Classification of Anemias
Anemia is classified by RBC morphology and underlying mechanism, guiding the laboratory workup and differential diagnosis.
Anemias
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